05/27/2026
In one peer-reviewed study of residents with advanced dementia in 22 Boston-area nursing homes, about 37 percent received at least one medication considered potentially inappropriate for their condition. That does not mean every nursing home resident faces that exact rate. It is a serious warning sign about medication oversight.
The study is Tjia and colleagues, "Daily Medication Use in Nursing Home Residents with Advanced Dementia," published in the Journal of the American Geriatrics Society. The researchers followed 323 residents with advanced dementia across 22 Boston-area nursing homes prospectively for 18 months. They reviewed each resident's medication record against established criteria for medications considered "never appropriate" in advanced dementia, meaning drugs whose burdens outweigh their benefits given the resident's prognosis and condition. The findings: residents were prescribed an average of 5.9 daily medications, and 37.5 percent received at least one medication considered never appropriate in advanced dementia. The most common inappropriate prescriptions were acetylcholinesterase inhibitors and lipid-lowering agents. Twenty-eight percent of residents took antipsychotics daily.
That last finding deserves attention. Federal regulations, including 42 CFR § 483.10 and § 483.25, prohibit the use of any drug as a chemical restraint imposed for purposes of discipline or convenience and not required to treat the resident's medical symptoms. Antipsychotics, in particular, carry FDA black box warnings for increased mortality in elderly patients with dementia-related psychosis. When an antipsychotic shows up on a chart, the question for families is whether the medication is treating a documented medical symptom or quieting a resident the facility finds difficult to manage.
Here is what families can do. First, if you are the resident or the resident's authorized representative, ask for a complete medication list and the documented reason each drug is being administered. Under 42 CFR § 483.10, residents and their legal representatives have the right to access clinical records within 24 hours, excluding weekends and holidays.
Second, if your parent or loved one suddenly seems sedated, withdrawn, or "not themselves," ask the care team whether anything has changed in the medication regimen. Sudden behavioral changes after admission or after a transition in care are worth investigating.
Third, do not assume a medication is appropriate just because it appears on a chart. Ask what it is, what risk it carries, and whether it is still necessary. Some medications appropriate for one stage of a condition become inappropriate as the condition progresses.
If you have questions about the list, inquire with your loved one's medical care provider. Ideally, ask for a formal medication review.
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This is general information, not legal or medical advice.